Fri Jan 30 2026

16 articles - From Friday Jan 23 2026 to Friday Jan 30 2026

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Pancreatology
Obesity as a risk and prognostic factor for disease progression in intraductal papillary mucinous neoplasm (IPMN): A systematic review and meta-analysis.

This meta-analysis reveals that obesity and overweight may be associated with the risk of progression of IPMN, as well as to the likelihood of malignancy in patients undergoing surgery for IPMN. Surveillance programs should therefore take obesity into account as a potential risk factor for progression of IPMNs.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr
Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial.

Leucine supplementation does not attenuate the decline in daily MPS rates or muscle mass during short-term limb immobilization in young or older adults. Clinical trial registry This trial was prospectively registered at Netherlands Trial Register as ID NL-OMON45771.

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Metabolome contribution to sex differences in the link between alcohol consumption and type 2 diabetes: a prospective analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Our results suggested distinct blood metabolomic signatures associated with alcohol consumption in females and males, which might contribute to sex differences in the relationship between alcohol consumption and T2D.

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Inflamm Bowel Dis
Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients.

Taken together, the culturing of patient biopsies into ALI colonoid monolayers provides a powerful model to assess human colonic mucosal development, healing, homeostasis, and mucus barrier function, revealing that UC-derived colonoid monolayers display a range of developmental and functional defects that persist in the absence of inflammation.

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Distinct Effects of Autologous Hematopoietic Stem Cell Transplantation on T Cell Composition and Profile in Refractory Crohn's Disease.

Autologous hematopoietic stem cell transplantation had pronounced effects on the peripheral T cell composition, especially in responders. Changes in T cell subset composition were more pronounced than changes in the functional T cell profile.

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J Crohns Colitis
Association between endo-histological outcomes and colonic mucosal transcriptomic profiles in patients with ulcerative colitis receiving filgotinib.

Filgotinib improved endo-histological outcomes in patients with UC, with a dose-dependent effect on transcription. Gene expression changes and enriched pathways suggest that achieving endoscopic and histological endpoints in patients receiving FIL was associated with the restoration of mucosal homeostasis.

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Comparative analysis of inflammatory bowel disease patient and service reported quality of care using 2019 and 2023 UK benchmarking data from more than 26,000 adult patient respondents and 154 IBD services.

This data underscores the importance of assessing lived experience and the care quality perception gap between patients and service providers. Regular benchmarking including PREMs should be used to drive and assess service-level, national and international quality improvement initiatives.

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Mechanistic insights into FMT for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial.

Colonic FMT is a more effective delivery route than nasogastric administration. Clinical response is driven by the engraftment of immunomodulatory bacteria that restore a healthy host-microbe dialogue, providing rationale for developing targeted microbial therapeutics.

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Pancreatology
Cirrhosis of the liver adversely affects the clinical outcomes in patients with acute pancreatitis: A propensity-matched nationwide analysis (2016-2020).

Patients with decompensated cirrhosis had higher odds of mortality, higher healthcare resource utilization, and worse clinical outcomes compared to those without cirrhosis. Patients with compensated cirrhosis had higher odds of portal vein thrombosis, GI bleeding, and blood transfusion. Complications of portal hypertension are likely the primary drivers behind increased odds of mortality in cirrhotic patients with AP. Patients with decompensated cirrhosis also seem to be at a higher risk of complications due to AP.

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Patient experience with endoscopic ultrasound and magnetic resonance cholangiopancreatography for pancreatic cancer screening (The PATRIOT study).

Almost 60 % of patients prefer one screening modality over the other, with a trend towards screening patients favoring EUS and cyst surveillance patients MRCP. These findings support a patient-centered individualized approach to pancreatic cancer screening.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Pancreatology
From static snapshots to spatial evolution: reconstructing the malignant progression from IPMN to invasive PDAC.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Clin Nutr
From the American Society for Nutrition.

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Inflamm Bowel Dis
In Memoriam Kim Isaacs.

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Ustekinumab use in lactation: drug pharmacokinetics and normal development in exposed infants.

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Pancreatology
Histopathological evidence of pancreatic ischemia in patients with heart failure: A post-mortem case-control study.

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Surgery vs endoscopy for chronic pancreatitis: Long-term outcomes in a propensity-matched Chinese cohort.

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Letters&Replies

Letters to the editors and authors’ replies